What is a Generic in Canada? Health Canada (the Canadian regulatory board) evaluates every Canadian generic for their safety, effectiveness, and quality. Every generic used in Canada has the same medical ingredients as their brand name counterpart and is considered bioequivalent to the brand name medication. The quality standards for brand name drugs and generic drugs are the same. All of the ingredients, facilities, and manufacturing processes must meet Canadian federal guidelines for Good Manufacturing Practices. In addition, Canadian generic manufacturers must perform 'comparative bioavailability' studies to demonstrate that their generic products deliver the same amount of medicinal ingredient at the same rate as the brand name medication. Nearly 45% of all prescriptions filled in Canada use generic medication and some hospitals exclusively use generic drugs. For more information, please visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/med-gen-eng.php
Celebrex (pronounced as CELL-le-brex)
Celecoxib (pronounced as CELL-le-cox-ib)
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What is Celebrex used for?
Celebrex is used for pain due to spondylitis, rheumatoid arthritis, and osteoarthritis. It may also be used for short term management of moderate to severe pain due to trauma (ex. sprains), pain after dental extraction, or postoperative orthopaedic pain.
What is the mechanism of action for Celebrex?
Celebrex is a NSAID (nonsteroidal anti-inflammatory drug) that helps to manage pain, fever, and inflammation. Specifically, Celebrex inhibits COX-2 (Cyclooxygenase-2) receptors which are present in high quantities in inflamed tissues. At Canadian recommended doses, Celebrex does not affect COX-1, which mediates platelet aggregation and maintains a gastrointestinal mucosal barrier.
How to use Celebrex
As with all medication, there are patient specific considerations to review before starting Celebrex. In general, the recommended dose is 200mg either as a single dose or divided twice daily. Celebrex is contraindicated in the peri-operative setting, during the third trimester of pregnancy, women who are breastfeeding, patients with heart failure, hypersensitive/allergy to any of its components or sulfonamides, and patients who are allergic to ASA or other NSDAIDs. People who have active gastrointestinal/cerebrovascular bleeding should also avoid Celebrex. In addition, Celebrex is contraindicated for patients who have IBD, severe/active liver disease, severe renal disease, and hyperkalemia.
If you miss one or more doses, continue regimen as soon as possible then take your next scheduled dose. Do not increase your dose to compensate for the missed doses.
Celebrex alternatives and similar drugs
As Celebrex requires a prescription, many patients ask for over-the-counter alternatives for this medication. Advil (ibuprofen) or Aleve (naproxen) can be substituted in certain situations. Advil and Aleve may be more suitable for mild to moderate pain. Both of these options may be more affordable depending on your insurance coverage.
What are some common side effects of Celebrex?
Celebrex may cause drowsiness or fatigue. It may also make you more sensitive to sunlight which may cause sunburns, itching, or vision changes.
These side effects may be more prominent if used for a long time or when used in larger doses.
Please report any symptoms that you think may be a side effect to your health care provider.
Should Celebrex be taken with food?
Celebrex can be taken with or without food.
Can I drink alcohol when taking this medication?
You should not drink alcohol as it may increase the likelihood of developing stomach problems.
What are some common drug interactions of Celebrex?
Please notify your health care provider of your entire medication history before starting Celebrex.
The following is NOT a complete list of possible interactions: ASA, NSAIDs, Antacids, Proton pump inhibitors, antidepressants, blood pressure medication, blood thinners, corticosteroids, cyclosporin, digoxin, diuretics, fluconazole, lithium, tacrolimus, dextromethorphan.
Celebrex pregnancy safety and nursing implications
Celebrex is contraindicated in the third trimester due to the possibility of causing premature closure of the ductus arteriosus. Caution use during the first and second trimester as there are no adequate studies to support its use.
Celebrex is present in low levels in breastmilk and, because the amount ingested by the infant are small, is not expected to cause side effects in breastfed infants. At the same time, both the mother and the infant should be monitored throughout therapy. Celebrex should be stopped immediately at the first sign of rash in the infant. Reassessment of benefit and risk should be performed regularly.
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Information contained here on this page is for informational purpose only. Always speak with your Doctor about the usage of your medication.