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Linzess (Linaclotide) 145mcg

Brand Choice

Product from Canada

Linzess (Linaclotide)

Manufactured by: allergan

Marketed as: Constella in Canada

From $4.99 USD per Capsule(s)

CAN NOT BE SPLIT Must be taken in existing form.


Generic Choice

Product from Canada

No Generic Alternative Available

No generic alternative is available for this drug.

What is a Generic in Canada? Health Canada (the Canadian regulatory board) evaluates every Canadian generic for their safety, effectiveness, and quality. Every generic used in Canada has the same medical ingredients as their brand name counterpart and is considered bioequivalent to the brand name medication. The quality standards for brand name drugs and generic drugs are the same. All of the ingredients, facilities, and manufacturing processes must meet Canadian federal guidelines for Good Manufacturing Practices. In addition, Canadian generic manufacturers must perform 'comparative bioavailability' studies to demonstrate that their generic products deliver the same amount of medicinal ingredient at the same rate as the brand name medication. Nearly 45% of all prescriptions filled in Canada use generic medication and some hospitals exclusively use generic drugs. For more information, please visit

Linzess 145 mcg

Strengths available

Brand name

Linzess (pronounced as Lin-zess)

Generic name

Linaclotide (pronounced as Lin-ak-low-tide)

Manufacturer Information



About Linzess 145 mcg

What is Linzess used for?

Linzess, also known by its chemical name linaclotide, belongs to a class of drugs known as guanylate cyclase-C agonists. Linzess is used to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome associated with constipation (IBS-C). These diseases can result in painful stomach pains, and Linzess can alleviate these types of belly pains.

How does Linzess work?

The active ingredient of Linzess is linaclotide. Linzess is poorly absorbed when taken orally and hence remains in the gastrointestinal tract, also known as the lumen. It works locally by directly affecting the inner cells, also known as the epithelium, of the gastrointestinal tract. Linzess works by causing ions (such as Chloride Cl- an bicarbonate HCO3-) to move out of these cells and into the gut, where they attract water to soften stool and accelerate bowel movements. In addition, Linzess has an analgesic effect, reducing pain, on the inner lining of the gut by calming pain-sensing nerves.

How to take Linzess?

LInzess is taken orally. Your doctor will set your dose depending on what condition is being treated. Below shows the general Linzess dosing as set in the monograph:

  • For irritable bowel syndrome with constipation, a dose of 290 mg is given once daily.
  • For chronic idiopathic constipation a dose of 145 mg is given once daily.
  • A dose of 72 mg is only used for individuals who are abnormally sensitive to the higher doses. 

If the dose is missed do not use double the dose, just wait and take the next dose at the scheduled time.

Is Linzess consdiered a laxative?

Linzess is not considered a laxative. Linzess is poorly absorbed when taken orally, which is great so that it stays in the gastrointestinal tract affecting the intestine directly. Laxative are generally classified as either bulk-forming laxatives, lubricants, osmotic laxatives, stimulant laxatives, stool softeners, or combinations thereof. These agents affect the stool directly, whereas Linzess affects the biophysiology of the lumen or the inside of the intestine, stimulating it to secrete salt ions that move water into the lumen and soften the stool indirectly; this also results in accelerated bowel movements.

What are the side effects of Linzess?

Diarrhea is the most common side effect. Less common are abdominal pain, flatulence, and other gastrointestinal disturbance.

What foods to avoid with Linzess?

Linzess if best taken on an empty stomach 30 min before breakfast. Having a high fat breakfast with Linzess, for example, results in looser stools.

Can I use probiotics with Linzess?

Linzess has not shown to react with any other medications, food, or herbal products. Some people sprinkle the beads on yogurt for ease of swallowing. There should be no issue to use probiotics with Linzess, unless you are allergic to either Linzess or the probiotic.

What drugs interact with Linzess?

None, since Linzess is not readily absorbed by the body, it does not show in blood plasma, hence does not interact with other drugs or herbal medications.


How to buy Linzess from an Online Pharmacy in Canada?

You can buy brand name Linzess in Canada for much less than in the USA. However, in America, Linzess is the brand name of Linaclotide, which in Canada has the brand name Constella, they are the same medication both made by Allergan. No need to look for discounts, coupons, assist cards, or other gimmicks when buying Linzess from Canada Cloud Pharmacy. We don't play any of those games, we simply provide the lowest price for Linzess so that you know you are getting the best price up front.

Now you can easily and simply order online from a real brick and mortar pharmacy in Canada that delivers to your home in the United States, or anywhere in the world. Ordering a prescriptions online from Canada has never been easier.



Are there alternatives to Linzess?
An alternative of Linzess in the same class is Trulance, or plecanatide, which is, however, only indicated for chronic constipation and not IBS. Medications in other classes used to treat both chronic constipation and constipation induced irritable bowel syndrome include Motegrity/Resolor (prucalopride), For opioid induced chronic constipation the following alternative can be used in place of Linzess Methylnaltrexone (Relistor), Movantik (naloxegol), Amitza (lubiprostone), and Naldemedine (Symproic).
Who can not use Linzess?
Patients under 6 years of age should not use Linzess at all, and it is not recommended for children between the ages of 6-18. Patients with a history or suspected gastrointestinal obstruction.
How fast will Linzess work?
For relief of constipation, Linzess should show improvements in bowel movement with in the first week. For other abdominal issues the results may take longs and should be periodically reassessed by a doctor.
How to take Linzess if you have difficulty swallowing.
Linzess capsules can be opened and the beads can be sprinkled onto soft food like yoghurt or applesauce and swallowed whole. The beads should never be crushed or chewed.
Why is Linzess called Constella the same medication?
Yes Linzess and Constella are the same product actually made by the same company, Allergan. Buying Linzess in Canada is much cheaper than buying from America. As such the marketing of certain products can vary so there is less (or more, depending on how you look at it) confusion.



Buy Linzess 145 mg from Canada 

Information contained here on this page is for informational purpose only. Always speak with your Doctor about the usage of your medication.