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Wellbutrin XL 300mg

Brand Choice

Product from Canada

Wellbutrin XL

Manufactured by: bausch health

From $2.11 USD per tablet(s)

CAN NOT BE SPLIT Must be taken in existing form.


Generic Equivalent

Product from Canada

Bupropion XL 300mg

From $0.99 USD per tablet(s)

CAN NOT BE SPLIT Must be taken in existing form.


What is a Generic in Canada? Health Canada (the Canadian regulatory board) evaluates every Canadian generic for their safety, effectiveness, and quality. Every generic used in Canada has the same medical ingredients as their brand name counterpart and is considered bioequivalent to the brand name medication. The quality standards for brand name drugs and generic drugs are the same. All of the ingredients, facilities, and manufacturing processes must meet Canadian federal guidelines for Good Manufacturing Practices. In addition, Canadian generic manufacturers must perform 'comparative bioavailability' studies to demonstrate that their generic products deliver the same amount of medicinal ingredient at the same rate as the brand name medication. Nearly 45% of all prescriptions filled in Canada use generic medication and some hospitals exclusively use generic drugs. For more information, please visit

Wellbutrin XL 300mg              

*Note NEW bottle label appearance as of August 2022 - the tablets are the same*

Strengths available

Brand name

Wellbutrin XL (pronounced as well-biew-trin)

Generic name

bupropion (pronounced as biew-pro-pee-on)

Manufacturer Information


About Wellbutrin XL 300mg

Wellbutrin XL uses

Wellbutrin XL, which contains the active ingredient bupropion, is classified as an antidepressant. Wellbutrin XL is used to treat major depressive disorder (MDD) and prevention of seasonal major depressive episodes in patients 18 years and older. Use of Wellbutrin XL should be avoided in patients with a history of seizure disorders or patients with bulimia or anorexia nervosa due to its potential to increase the risk of seizures. Wellbutrin XL should also not be used in patients undergoing withdrawal from sedatives, alcohol, or benzodiazepines.

How does Wellbutrin XL work?

The exact mechanism of Wellbutrin XL is not clearly understood. Leading experts believe that Wellbutrin XL works by inhibiting the reuptake of dopamine and norepinephrine from synapses between neurons. This helps to resolve the imbalance of neurotransmitters that are released from patients with depression. The mechanism of action of Wellbutrin XL is unique amongst antidepressants because of its effects on dopamine – other antidepressants such as SSRIs (selective serotonin receptor inhibitors) and TCAs (tricyclic antidepressants) are not documented to have clinical significant effects on dopamine. Wellbutrin XL has a unique drug delivery system that allows for the medication to remain in your body for 24 hours after a single dose. It is crucial to not disturb this unique coating by chewing, cutting, or crushing your tablets.

How do I use Wellbutrin XL?

Patients new to Wellbutrin XL usually begin therapy at 150mg daily in the morning. After 1 week of treatment, your doctor may want to increase your dose to 300mg daily in the morning or maintain 150mg daily if you experience side effects with the higher dose. Patients who use Wellbutrin XL seasonally usually start their treatment in fall, before any onset of system, continue their medication through winter, and gradually taper and discontinue doses by spring.

If you forget a dose, skip the dose and take your next dose the following day at your regularly scheduled time. Do not take more than 1 dose per day.

What's the difference between Wellbutrin XL and Wellbutrin SR?

Wellbutrin XL contains bupropion extended release whereas Wellbutrin SR contains bupropion sustained release. Despite their similar names, these medication are not interchangeable and each have their own therapeutic advantages. Wellbutrion XL is dosed once daily and does not have a generic available. Because Wellbutrin XL stays in your body over a longer period with fewer fluctuations in concentrations, it causes fewer side effects. Wellbutrin SR is taken twice daily and there are generics available. Studies have shown that once daily dosing of Wellbutrin XL is bioequivalent to twice daily dosing of Wellbutrin SR and three-times daily dosing of bupropion regular release tablets.

What are common side effects of Wellbutrin XL?

Common side effects of Wellbutrin XL are dry mouth, constipation, nausea, insomnia, anxiety, dizziness, and decreased appetite. Some patients may also experience flatulence, headache, or sinusitis. Some rare, but serious, side effects you should watch out for include: palpitations, chest pain, rash, blurred vision, anaemia, irregular heart rate, irregular menstruation, genital rash, erectile dysfunction, wheezing, swelling, and peripheral coldness. This is not a complete list. If you notice any side effects, please consult with your doctor.

Wellbutrin XL and food

You can take Wellbutrin XL with or without food.

Can I drink alcohol when taking Wellbutrin XL?

As is the case with most antidepressants, it is not advisable to use Wellbutrin XL and drink alcohol at the same time. Although alcohol does not have a direct interaction with Wellbutrin XL, it does increase the risk of side effects, including increasing your risk of seizures, hallucinations, suicidal thoughts, and anxiety. At the same time, sudden discontinuation of alcohol, if you are a regular drinker, is not recommended either as it can similarly increase your risk of seizures.

Wellbutrin XL drug interactions

Wellbutrin XL is metabolized by CYP2B6 and has interactions with all other drugs metabolized by this enzyme such as, but not limited to, most antidepressants, beta-blockers, antipsychotics, and antiarrhythmics. The clinical significance of these interactions is not well studied so please speak with your doctor for individual concerns. General recommendations suggest to start with lower doses of Wellbutrin XL, or the medication that it is interacting with, and monitor the effects. Wellbutrin XL should not be used with tamoxifen, thioridazine, and MAO inhibitors.

Order Wellbutrin XL online from Canada to the USA

Here at Canada Cloud Pharmacy, we frequently hear stories from USA patients about the absurd prices their local pharmacies charge for Wellbutrin XL, a medication that they depend on for daily life. Everyone knows how important it is to take your Wellbutrin XL regularly as prescribed but sky high prices in USA make it unfeasible for many patients to do so. Even patients with insurance, patient assistance programs, and coupons, are looking North-bound to Canada to fill their Wellbutrin XL prescription online with a Canadian Pharmacy.

Canada Cloud Pharmacy is a real brick-and-mortar store located in Vancouver, BC that serves its local and international patients. Unlike many other “pharmacies” that hide behind their websites, you can visit Canada Cloud Pharmacy in person anytime you’re in Vancouver and see the staff who prepare your orders everyday. Ask us about our in-store pick up option if you’re visiting Vancouver! If you would like to have your medication delivered to your door, you can choose to do so by ordering online and completing our quick check out process. Call now to speak with a pharmacist and learn about how you can save with Canadian drug prices.


What is the half-life of Wellbutrin XL?
The half-life of Wellbutrin XL is approximately 21 hours and can vary by 40% if you have alcoholic liver disease. This long half-life is unique to Wellbutrin XL because of the special matrix delivery system coated on the tablets. It is important to not confuse half-life with how long it takes Wellbutrin XL to work. The onset of therapeutic effects may take 4 to 6 weeks.
Does Wellbutrin XL cause Weight loss?
With FDA’s approval of Contrave (combination of naltrexone and bupropion), an increasing number of patients are interested as to whether Wellbutrin XL (bupropion) alone can help with weight loss. Even though Wellbutrin XL and Contrave share the same ingredient, studies reporting both weight gain and weight loss can be found for Wellbutrin XL. One possibility as to why Wellbutrin XL does not produce the same weight loss effects as Contrave is that the 2 medication contain very different amounts of bupropion. Another possibility is that both naltrexone and bupropion are required to regulate food intake and reward systems in the brain.
Has Wellbutrin XL got a generic?  Why does the generic for Wellbutrin not work as well as the brand?
The generic for Wellbutrin XL, known as bupropion XL, has a poor reputation for causing side effects and complications in patients previously stable with the brand name Wellbutrin XL. This is likely due to Wellbutrin XL’s complicated coating, its risky side effects, and how these factors altered FDA’s usual drug approval process. Wellbutrin and bupropion XL are available as 150mg and 300mg tablets. It is known that Wellbutrin/bupropion increases the risk of seizures and this risk increases as dose increases. As a result, during generic drug testing, the FDA gave special permission for generic manufacturers to test their 150mg tablets and extrapolate the data for their 300mg tablets. While studies showed small differences with how much time it took the 150mg brand and generic tablets to reach their peak concentrations, this difference was much more pronounced for the 300mg version and many patients feel that the generic is less effective or causes more side effects than their brand name Wellbutrin XL. In 2012, generic bupropion XL 300mg manufactured by TEVA was removed from the USA market due to its differences from the brand name tablet. Bupropion XL 150mg continue to be available in USA despite their small differences. Meanwhile, in Canada, generic bupropion XL accounts for 2/3 of total bupropion XL and Wellbutrin XL prescriptions.
Can Wellbutrin XL be cut in half?
Wellbutrin XL tablets should not be cut, chewed, or crushed, as any tampering with the tablets may affect the release rate of bupropion.
Wellbutrin XL and smoking
There is no evidence to suggest that Wellbutrin XL works differently in patients who smoke than in the general population. Another formulation of bupropion, known as Zyban, is used as a smoking cessation aid along with nicotine replacement therapy.

Buy Wellbutrin XL 300mg from Canada 

Information contained here on this page is for informational purpose only. Always speak with your Doctor about the usage of your medication.