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Xiidra (Lifitegrast) Ophthalmic Solution (0.2mL Per Vial) 5%

Brand Choice

Product from Canada

Xiidra (Lifitegrast) Ophthalmic Solution (0.2mL per Vial)

Manufactured by: shire biochem

One box(es) contains 60 vial(s)

From $266.66 USD per box(es)

Single-use containers should be kept in the original foil pouch to protect from light. Any opened single-use container should be discarded immediately after use.

CAN NOT BE SPLIT Must be taken in existing form.


Generic Choice

Product from Canada

No Generic Alternative Available

No generic alternative is available for this drug.

What is a Generic in Canada? Health Canada (the Canadian regulatory board) evaluates every Canadian generic for their safety, effectiveness, and quality. Every generic used in Canada has the same medical ingredients as their brand name counterpart and is considered bioequivalent to the brand name medication. The quality standards for brand name drugs and generic drugs are the same. All of the ingredients, facilities, and manufacturing processes must meet Canadian federal guidelines for Good Manufacturing Practices. In addition, Canadian generic manufacturers must perform 'comparative bioavailability' studies to demonstrate that their generic products deliver the same amount of medicinal ingredient at the same rate as the brand name medication. Nearly 45% of all prescriptions filled in Canada use generic medication and some hospitals exclusively use generic drugs. For more information, please visit


Strengths available

50 mg/ml

Brand name

Xiidra (pronounced as ex-EE-drah)

Generic name

Lifitegrast (pronounced as Le-FIT-ah-grast)

Manufacturer Information

Shire Pharma

About Xiidra

What is Xiidra used for?

Xiidra, which contains the active ingredient lifitegrast, is an eyedrop used to manage dry eyes (keratoconjunctivitis sicca) caused by insufficient tear production or abnormal tear makeup.

How does Xiidra work?

The exact mechanism of action of Xiidra for dry eye disease is not known. Studies suggest that it may be due to its effect on LFA-1 proteins on leukocytes. By blocking the LFA-1 protein, Xiidra decreases inflammation through a cascade of reactions involving the intercellular adhesion molecule-1 (ICAM-1) and T-cells.

How do I use Xiidra?

  • Wash your hands before starting and avoid touching the tip of each single-use container.
  • Remove 1 container from the strip and hold the container upright.
  • Tap on the container to make sure all the liquid is at the bottom and then twist off the tab to open the container.
  • Tilt your head backwards and gently pull down your lower eyelid.
  • Let 1 drop fall into your eye and repeat for your other eye.
  • Discard the remaining solution immediately after your dose.
  • Please make sure to remove your contact lenses before using Xiidra (your contacts may be re-inserted 15 minutes after dosing).

The recommended dose for Xiidra is 1 drop in each eye twice a day.

If you forget a dose of your Xiidra, take it as soon as you remember. If it’s almost time for your next dose, then skip the missed dose and proceed with your next scheduled dose.

Does Xiidra cause burning and irritation?

Studies show that up to 25% of patients using Xiidra experience some form of irritation in their eyes. Some patients experience irritation as soon as they apply their first drop but this usually resolves after a few seconds.

If you experience irritation that worsens or does not go away, talk to your doctor – they may recommend a different drug for you.

What are possible side effects of using Xiidra?

Common side effects of Xiidra include: eye irritation/pain, unusual taste in mouth, blurred vision, itchy/red eyes, increase in tears, headache, sensitivity to light. If you experience any wheezing, difficulty breathing, or a swollen tongue, seek immediate medical attention as you may be allergic to Xiidra.

What's the difference between Xiidra vs Restasis?

Xiidra vs Restasis; Xiidra and Restasis work at different points of the inflammation cycle. Xiidra works much earlier in the cycle and, as a result, patients experience benefits from Xiidra quicker than they do with Restasis.
It may take Restasis patients up to 16 weeks to experience symptom improvement whereas Xiidra patients experience improvements in 6-12 weeks, sometimes as quickly as 2 weeks.
If you wear contact lenses, your doctor may choose Xiidra as you may insert your lens 15 minutes after instilling your eye drops (contact lens are not recommended for Restasis patients). Even though burning and stinging is commonly reported with Xiidra use, it is even more commonly reported with Restasis use.

What's the difference between Xiidra vs Systane drops or other alternatives?

Xiidra vs Systane; Systane, and other non-prescription artificial tear drops, are used for temporary relief of discomfort and irritation but do not treat the underlying cause of dry eye disease. Over-the-counter eye drops my also contain ingredients that temporarily improve the appearance of eyes (ex. Decrease redness) but, without managing the root cause, sometimes these drops can mask symptoms and prevent therapy.

Xiidra interactions

Xiidra doesn’t have any direct interaction with other medications. However, if you’re using another eye drop, wait at least 10 minutes before you apply the next medication.

How to order Xiidra from Canada

A carton of Xiidra can cost $500-$600 in USA, creating a high financial barrier stopping patients from trying a new and possibly very effective therapy. This is where Canada Cloud Pharmacy can help. Canada Cloud Pharmacy is a licensed, brick-and-mortar pharmacy that’s been serving the local community for over 6 years. Canada Cloud pharmacy also allows USA and international patients to order online, have Xiidra delivered to their door, while enjoying Canadian Xiidra prices. Whether you have a Xiidra manufacturers coupon, a savings card, or a Xiidra patient assistance program, make sure to check prices online as you can still save with Canadian prices.

Canada Cloud Pharmacy only sends Xiidra direct from Canada and we offer the same medication online as we do to our local in-store patients. Order your Xiidra online and it can be delivered to your door in as little as 5 days. Save on Xiidra and other medication now by speaking with a real pharmacist today.


Does Xiidra cause dry mouth?
In clinical studies, dry mouth was not a side effect in people using Xiidra. Dry mouth can be caused by certain diseases or conditions that Xiidra is often used to treat. However, up to 5 percent of people in clinical studies had dysgeusia. This condition, which is also called parageusia, causes people to have a metallic or salty taste in their mouth. If you have changes in taste while using Xiidra, talk with your doctor about ways to help improve the condition.
Does Xiidra cause hair loss?
No, Xiidra does not cause hair loss or eye lash loss.
Do you have a Xiidra free trial?
Sorry, we do not offer samples or trials for medication. However, your prescriber might - please speak with your doctor for more details.
Where can I find Xiidra prescriber information and patient information?
All medication from Canada Cloud Pharmacy are sent with their original packaging so a copy of Xiidra patient information will be included in your parcel. You can find the prescribing information and full monograph here:
Is Xiidra an immunosuppressant?
Xiidra is NOT considered an immunosuppressant despite its action with T-Cells.



Buy Xiidra  from Canada 

Information contained here on this page is for informational purpose only. Always speak with your Doctor about the usage of your medication.