Motilium (Domperidone) 10mg
What is a Generic in Canada? Health Canada (the Canadian regulatory board) evaluates every Canadian generic for their safety, effectiveness, and quality. Every generic used in Canada has the same medical ingredients as their brand name counterpart and is considered bioequivalent to the brand name medication. The quality standards for brand name drugs and generic drugs are the same. All of the ingredients, facilities, and manufacturing processes must meet Canadian federal guidelines for Good Manufacturing Practices. In addition, Canadian generic manufacturers must perform 'comparative bioavailability' studies to demonstrate that their generic products deliver the same amount of medicinal ingredient at the same rate as the brand name medication. Nearly 45% of all prescriptions filled in Canada use generic medication and some hospitals exclusively use generic drugs. For more information, please visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/med-gen-eng.php
Domperidone 10 mg
Motillium (pronounced as Mo-till-lee-um)
Domperidone (pronounced as Dom-pear-ree-done)
Various Canadian Approved Generic Manufacturers
About Domperidone 10 mg
What is Domperidone?
Domperidone is motility drug used to treat a number of dysmotility related ailments. Domperidone is indicated in the treatment and management of upper gastrointestinal motility disorders associated with gastritis and gastroparesis. Domperidone is also used to counteract the gastrointestinal side-effects of dopamine agonists used to treat Parkinson's disease.
How does Domperidone work?
Domperidone's mechanism of action is due to its action as a dopamine antagonist that acts in the body peripherally. Domperidone works by stimulating peristalsis and increasing LESP (Lower Oesophageal Sphincter Pressure), to increase gastric motility and improve gastroduodenal coordination. This works to increase gastric emptying time and decrease small intestine transit to alleviate symptoms such as gastroparesis.
When should I take Domperidone?
Domperidone should be taken on an empty stomach, 30 minutes before meals. The usual dose of domperidone is one 10 mg tablet, three times a day, which is a total daily dose of 30 mg per day.
If you miss a dose of your domperidone take the dose as soon as you remember. If it's already time to take your next dose, skip the miss dose and continue taking the domperidone as usual. Do not double up on a dose of domperidone to make up for a missed dose.
How can I avoid Domperidone withdrawal?
Domperidone withdrawals have been reported in cases of domperidone high dosages for prolonged periods of time. Symptoms such as insomnia, tachycardia and anxiety have been reported on these withdrawals so it is important that you follow any titrating instructions your Doctor may prescribe for.
It is often recommended to titrate off domperidone slowly on a decreasing dose regimen to limit these adverse withdrawal effects. Discuss your withdrawal with your Doctor to see if this is necessary.
What are common side effects of Domperidone?
The most common side effects associated with domperidone are gastrointestinal in nature.
Domperidone side-effects include but are not limited to - diarrhea, nausea, abdominal cramping pain, dry mouth, itchy rash, and hyperprolactinemia.
A serious side effect that is always considered and should be screen for is the potential for domperidone to cause QTc prolongation.
Hyperprolactinemia with Domperidone
Domperidone may cause hyperprolactinemia, particularly with high dose usage for prolonged periods. Symptoms of hyperprolactemia with domperidone include enlarged breasts, breast tenderness, menstrual irregularities, galactorrhea, hypogonadism and gynecomastia.
Domperidone as a QT prolonging agent
It has long been know that domperidone may cause QTc prolongation and Torsade's de Pointes. QTc prolongation is effectively a delayed ventricular repolarisation which can cause tachycardia and most serious conditions. For this reason patients are often screened before starting domperidone for a susceptibility to this QT prolongation, by undertaking a ECG or EKG and Stress Test.
Domperidone should be avoided in patients who are predisposed to QT prolongation or would be under greater risk of QT prolongation and also avoided in patients who currently take medication that are considered QTc prolongation agents.
If you are taking domperidone and you suffer from syncope (fainting), seizures, palpitations or cardiac arrest ensure your Doctor is aware that you are taking domperidone.
Should I take Domperidone with or without food?
Is using domperidone for dysmotility it should be taken on an empty stomach 30 minutes before main meals for max efficacy.
Can I drink alcohol when taking Domperidone?
Speak with your Doctor about drinking alcohol with domperidone. Although it is not contradicted when taking domperidone, alcohol may make your motility symptoms worse. If you are not eliminating alcohol entirely try to limit the amount you drink at any one time.
As explained earlier, domperidone has some key potential interactions with certain medication which can cause serious, sometimes life-threatening complications. For this reason it is vital that you discuss all the medication you are currently taking, including any over the counter medication or supplements, with your Doctor and Pharmacist prior to receiving your domperidone.
Domperidone is a QT prolonging agent. It is contraindicated to use domperidone with another QT prolonging agents it would greatly increase the risk of QTc prolongation. QTc prolonging agent include but are not limited to Zofran (ondansetron), azithromycin, droperidol, escitalopram, citalopram, flupentixol, flecainide, Quinine, Quinidine, sotalol, amiodarone, cisapride, disopyramide, dronedarone, procainamide, etc. THIS LIST IS NOT COMPLETE.
You should also avoid grapefruit juice when taking domperidone. Grapefruit juice may spike the level of domperidone in the body and cause unwanted adverse effects.
Always inform your Doctor and Pharmacist of any medication you are currently taking.
The off label uses of Domperidone
Domperidone has been used for many years as an agent to induce lactation, to boost the milk supply when breast-feeding. This is an off-label use in Canada and as such is one that is not recommended or is not licensed for on the domperidone monograph. In mothers who are breast-feeding, domperidone has shown to enhance lactation in domperidone induced lactation. The doses for the induction of lactation using domperidone are usually higher than when treating motility issues such as gastroparesis. As increasing milk supply using domperidone is an off-label use, the dosage a standardized dosage is not given in the literature. Follow the advice of your Doctor in regards to the dosage they prescribed for you.
Ordering Domperidone from Canada
Domperidone is a medication that has been used for many years in many countries around the world for a variety of indications. Domperidone is not sold in the US because domperidone is not licensed for sale by the FDA. For this reason thousands of US patients with US prescription order domperidone from Canada.
US gastroenterologists often write prescriptions for domperidone for their patients aware that domperidone is not available in the States and expecting their patients to go to Canada to have their domperidone prescription filled. The only option for US patients that need domperidone and have a US prescription is to find a legitimate online Canadian Pharmacy, such as Canada Cloud Pharmacy, to fill and deliver their domperidone to the US.
Canada Cloud Pharmacy is run by a small team of Pharmacists and as such your domperidone prescription will be screened for any drug interactions and you will receive adequate counselling advice. Gastroenterologists in the States often recommend Canada Cloud Pharmacy as their preferred choice to fill domperidone prescriptions as we can be verified as a brick and mortar pharmacy that supplies domperidone ONLY from Canada. Chat with our online Canadian Pharmacy today to find out more.
Buy Domperidone 10 mg from Canada
Information contained here on this page is for informational purpose only. Always speak with your Doctor about the usage of your medication.