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Motilium (Domperidone) 10mg

No Brand Alternative Available

No brand product is available for this drug.

Generic Choice

Product from Canada

Motilium (Domperidone) 10mg

From $0.29 USD per Tablet(s)

CAN NOT BE SPLIT Must be taken in existing form.


What is a Generic in Canada? Health Canada (the Canadian regulatory board) evaluates every Canadian generic for their safety, effectiveness, and quality. Every generic used in Canada has the same medical ingredients as their brand name counterpart and is considered bioequivalent to the brand name medication. The quality standards for brand name drugs and generic drugs are the same. All of the ingredients, facilities, and manufacturing processes must meet Canadian federal guidelines for Good Manufacturing Practices. In addition, Canadian generic manufacturers must perform 'comparative bioavailability' studies to demonstrate that their generic products deliver the same amount of medicinal ingredient at the same rate as the brand name medication. Nearly 45% of all prescriptions filled in Canada use generic medication and some hospitals exclusively use generic drugs. For more information, please visit

Domperidone 10 mg

 Note for US patients:  

  Domperidone is an unapproved medication in the US, and is subject to FDA review when shipped. Please be aware there are no approved drug applications for this medication in the United States.

Strengths available         

10 mg

Brand name

Motillium (pronounced as Mo-till-lee-um)

Generic name

Domperidone (pronounced as Dom-pear-ree-done)

Manufacturer Information

Various Canadian Approved Generic Manufacturers

About Domperidone 10 mg

What is Domperidone?

Domperidone is motility drug used to treat a number of dysmotility related ailments. Domperidone is indicated in the treatment and management of upper gastrointestinal motility disorders associated with gastritis and gastroparesis. Domperidone is also used to counteract the gastrointestinal side-effects of dopamine agonists used to treat Parkinson's disease.

Domperidone is a dopamine antagonist that acts peripherally as an antiemetic and gastrokinetic.

How does Domperidone work?

Domperidone's mechanism of action is due to its action as a dopamine antagonist that acts in the body peripherally. Domperidone works by stimulating peristalsis and increasing LESP (Lower Oesophageal Sphincter Pressure), to increase gastric motility and improve gastroduodenal coordination. This works to increase gastric emptying time and decrease small intestine transit to alleviate symptoms such as gastroparesis.

When should I take Domperidone?

Domperidone should be taken on an empty stomach, 30 minutes before meals. The usual dose of domperidone is one 10 mg tablet, three times a day, which is a total daily dose of 30 mg per day.

If you miss a dose of your domperidone take the dose as soon as you remember. If it's already time to take your next dose, skip the miss dose and continue taking the domperidone as usual. Do not double up on a dose of domperidone to make up for a missed dose.

How can I avoid Domperidone withdrawal?

Domperidone withdrawals have been reported in cases of domperidone high dosages for prolonged periods of time. Symptoms such as insomnia, tachycardia and anxiety have been reported on these withdrawals so it is important that you follow any titrating instructions your Doctor may prescribe for.

It is often recommended to titrate off domperidone slowly on a decreasing dose regimen to limit these adverse withdrawal effects. Discuss your withdrawal with your Doctor to see if this is necessary.

What are common side effects of Domperidone?

The most common side effects associated with domperidone are gastrointestinal in nature.

Domperidone side-effects include but are not limited to - diarrhea, nausea, abdominal cramping pain, dry mouth, itchy rash, and hyperprolactinemia.

A serious side effect that is always considered and should be screen for is the potential for domperidone to cause QTc prolongation.

Hyperprolactinemia with Domperidone

Domperidone may cause hyperprolactinemia, particularly with high dose usage for prolonged periods. Symptoms of hyperprolactemia with domperidone include enlarged breasts, breast tenderness, menstrual irregularities, galactorrhea, hypogonadism and gynecomastia.

Domperidone as a QT prolonging agent

It has long been know that domperidone may cause QTc prolongation and Torsade's de Pointes. QTc prolongation is effectively a delayed ventricular repolarisation which can cause tachycardia and most serious conditions. For this reason patients are often screened before starting domperidone for a susceptibility to this QT prolongation, by undertaking a ECG or EKG and Stress Test.

Domperidone should be avoided in patients who are predisposed to QT prolongation or would be under greater risk of QT prolongation and also avoided in patients who currently take medication that are considered QTc prolongation agents.

If you are taking domperidone and you suffer from syncope (fainting), seizures, palpitations or cardiac arrest ensure your Doctor is aware that you are taking domperidone.

Should I take Domperidone with or without food?

Is using domperidone for dysmotility it should be taken on an empty stomach 30 minutes before main meals for max efficacy.

Can I drink alcohol when taking Domperidone?

Speak with your Doctor about drinking alcohol with domperidone. Although it is not contradicted when taking domperidone, alcohol may make your motility symptoms worse. If you are not eliminating alcohol entirely try to limit the amount you drink at any one time.

Domperidone Interactions

As explained earlier, domperidone has some key potential interactions with certain medication which can cause serious, sometimes life-threatening complications. For this reason it is vital that you discuss all the medication you are currently taking, including any over the counter medication or supplements, with your Doctor and Pharmacist prior to receiving your domperidone.

Domperidone is a QT prolonging agent. It is contraindicated to use domperidone with another QT prolonging agents it would greatly increase the risk of QTc prolongation. QTc prolonging agent include but are not limited to Zofran (ondansetron), azithromycin, droperidol, escitalopram, citalopram, flupentixol, flecainide, Quinine, Quinidine, sotalol, amiodarone, cisapride, disopyramide, dronedarone, procainamide, etc. THIS LIST IS NOT COMPLETE.

You should also avoid grapefruit juice when taking domperidone. Grapefruit juice may spike the level of domperidone in the body and cause unwanted adverse effects.

Always inform your Doctor and Pharmacist of any medication you are currently taking.

The off label uses of Domperidone

Domperidone has been used for many years as an agent to induce lactation, to boost the milk supply when breast-feeding. This is an off-label use in Canada and as such is one that is not recommended or is not licensed for on the domperidone monograph. In mothers who are breast-feeding, domperidone has shown to enhance lactation in domperidone induced lactation. The doses for the induction of lactation using domperidone are usually higher than when treating motility issues such as gastroparesis. As increasing milk supply using domperidone is an off-label use, the dosage a standardized dosage is not given in the literature. Follow the advice of your Doctor in regards to the dosage they prescribed for you.

Ordering Domperidone from Canada 

Domperidone is a medication that has been used for many years in many countries around the world for a variety of indications. Domperidone is not sold in the US because domperidone is not licensed for sale by the FDA. For this reason thousands of US patients with US prescription order domperidone from Canada.

US gastroenterologists often write prescriptions for domperidone for their patients aware that domperidone is not available in the States and expecting their patients to go to Canada to have their domperidone prescription filled. The only option for US patients that need domperidone and have a US prescription is to find a legitimate online Canadian Pharmacy, such as Canada Cloud Pharmacy, to fill and deliver their domperidone to the US.

Canada Cloud Pharmacy is run by a small team of Pharmacists and as such your domperidone prescription will be screened for any drug interactions and you will receive adequate counselling advice. Gastroenterologists in the States often recommend Canada Cloud Pharmacy as their preferred choice to fill domperidone prescriptions as we can be verified as a brick and mortar pharmacy that supplies domperidone ONLY from Canada. Chat with our online Canadian Pharmacy today to find out more.


Why is domperidone not available in the US?
Domperidone is not available in the States as it is not licensed for sale by the FDA.
How can I order domperidone from Canada?
Ordering domperidone in Canada online, direct from Canada Cloud Pharmacy requires a valid prescription, written by a licensed and contactable Doctor. If you have a prescription for domperidone from your US Doctor, you can search for domperidone you can place your order online or give us a call on our toll-free number 1800-901-0041.
Do I need a prescription for domperidone? Is domperidone over the counter?
In Canada you do need a prescription to attain domperidone. Domperidone was available over the counter in the UK until recent years, when it was reclassified as a prescription only medication. The fact that domperidone requires a lot counselling and initial monitoring as well screening for drug-drug interactions makes it essential for domperidone to be a prescription required medication.
Does domperidone cause weight gain?
Firstly, weight gain is not one of the listed side-effects of domperidone on the domperidone monograph however it has been used off-label for conditions such as anorexia nervosa. The rationale behind domperidone's usage in anorexia is that domperidone increases the rate of gastric emptying and as such decreases that bloating feeling or a feeling of fullness which allows anorexic patients to eat more without the distress they may normally feel. As this is an off-label use it is usually prescribed by a specialist. Never attempt to purchase or take domperidone without being prescribed by a licensed medical doctor.
Domperidone vs Reglan. Is domperidone better than Reglan?
Domperidone and Reglan (metoclopramide) are both prokinetic medications that act as dopamine antagonists. They are both used to treat similar issues caused by a motility issues. The main difference between Reglan and domperidone, which results in different therapeutic and side-effects, is the fact that domperidone only acts peripherally while Reglan crosses the blood brain barrier. As domperidone only acts peripherally it is a better candidate for many patients to help with peripheral gastrointestinal issues such as gastroparesis. As Reglan crosses the blood brain barrier it may cause psychological side-effects such as agitation and depression that domperidone does not cause.
What are the presenting symptoms of QTc prolongation when taking domperidone?
The presenting complaint of QT prolongation with domperidone can be a wide range of symtoms from breathlessness to fainting. Other symptoms of QT prolongation are palpitations, chest pain and seizure. Contact your Doctor immediately if you feel any of these symptoms or are concerned that you may be experiencing some unexplained effects of your domperidone.

Buy Domperidone 10 mg from Canada 

Information contained here on this page is for informational purpose only. Always speak with your Doctor about the usage of your medication.